2-Chloro-5-nitroquinoline → HCID 25018802, compound

HRID 2076282Notes

Reaction equation

HRID 2076282 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](Cl)=[N:9]2)([O-])=O.[Cl:15][C:16]1[S:20][C:19]([S:21](Cl)(=[O:23])=[O:22])=[CH:18][CH:17]=1.[NH2:25][C@H:26]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH2:28][CH2:27]1>>[C@H:26]1([NH:25][C:8]2[CH:7]=[CH:6][C:5]3[C:10](=[CH:11][CH:12]=[CH:13][C:4]=3[NH:1][S:21]([C:19]3[S:20][C:16]([Cl:15])=[CH:17][CH:18]=3)(=[O:23])=[O:22])[N:9]=2)[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH2:28][CH2:27]1

Participants

4

Reactant 3

HCID 3192512-Chloro-5-nitroquinolineHCID 27339255-Chlorothiophene-2-sulfonyl chlorideHCID 2733933(R)-(-)-1-Aminoindan

Product 1

HCID 25018802HCID 25018802, compound

Procedure

The title compound, MS: m/e=456.3 (M+H+), was prepared in accordance with the general method of example 1 from 5-nitro-2-chloroquinoline, 5-chlorothiophene-2-sulfonylchloride and (R)-1-aminoindane.

Sources & evidence

ORD record
ord-18de4d52dc604ccd9725e9eb43c1d5cd
Source dataset
uspto-grants-2011_04
Patent number
US07923561B2

Reaction notes

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