2-Chloro-5-nitroquinoline → HCID 67095769, compound

HRID 2076285Notes

Reaction equation

HRID 2076285 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](Cl)=[N:9]2)([O-])=O.[F:15][C:16]1[CH:17]=[C:18]([S:23](Cl)(=[O:25])=[O:24])[CH:19]=[C:20]([F:22])[CH:21]=1.[O:27]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:30]([NH2:37])[CH2:29][CH2:28]1>>[O:27]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:30]([NH:37][C:8]2[CH:7]=[CH:6][C:5]3[C:10](=[CH:11][CH:12]=[CH:13][C:4]=3[NH:1][S:23]([C:18]3[CH:17]=[C:16]([F:15])[CH:21]=[C:20]([F:22])[CH:19]=3)(=[O:25])=[O:24])[N:9]=2)[CH2:29][CH2:28]1

Participants

4

Reactant 3

HCID 3192512-Chloro-5-nitroquinolineHCID 27740583,5-Difluorobenzenesulfonyl chlorideHCID 49619573,4-Dihydro-2H-1-benzopyran-4-amine

Product 1

HCID 67095769HCID 67095769, compound

Procedure

The title compound, MS: m/e=468.1 (M+H+), was prepared in accordance with the general method of example 1 from 5-nitro-2-chloroquinoline, 3,5-difluorophenyl sulfonylchloride and 3,4-dihydro-2H-chromen-4-ylamine.

Sources & evidence

ORD record
ord-280033025f684200a1f299cdfec3aa08
Source dataset
uspto-grants-2011_04
Patent number
US07923561B2

Reaction notes

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