2-Chloro-5-nitroquinoline → HCID 25018541, compound

HRID 2076286Notes

Reaction equation

HRID 2076286 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](Cl)=[N:9]2)([O-])=O.[F:15][C:16]1[CH:17]=[C:18]([S:23](Cl)(=[O:25])=[O:24])[CH:19]=[C:20]([F:22])[CH:21]=1.[NH2:27][C@H:28]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH2:30][CH2:29]1>>[F:15][C:16]1[CH:17]=[C:18]([S:23]([NH:1][C:4]2[CH:13]=[CH:12][CH:11]=[C:10]3[C:5]=2[CH:6]=[CH:7][C:8]([NH:27][C@H:28]2[C:36]4[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=4)[CH2:30][CH2:29]2)=[N:9]3)(=[O:25])=[O:24])[CH:19]=[C:20]([F:22])[CH:21]=1

Participants

4

Reactant 3

HCID 3192512-Chloro-5-nitroquinolineHCID 2733933(R)-(-)-1-AminoindanHCID 27740583,5-Difluorobenzenesulfonyl chloride

Product 1

HCID 25018541HCID 25018541, compound

Procedure

The title compound, MS: m/e=452.0 (M+H+), was prepared in accordance with the general method of example 1 from 5-nitro-2-chloroquinoline, 3,5-difluorophenyl sulfonylchloride and (R)-1-aminoindane.

Sources & evidence

ORD record
ord-09c8aee9406e47d3ba13a16ea3463f17
Source dataset
uspto-grants-2011_04
Patent number
US07923561B2

Reaction notes

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