2-Chloro-5-nitroquinoline → Rac-3,4,5-trifluoro-n-[2-(7-methoxy-indan-1-ylamino)-quinolin-5-yl]-benzenesulfonamide

HRID 2076291Notes

Reaction equation

HRID 2076291 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](Cl)=[N:9]2)([O-])=O.[F:15][C:16]1[CH:17]=[C:18]([S:24](Cl)(=[O:26])=[O:25])[CH:19]=[C:20]([F:23])[C:21]=1[F:22].[CH3:28][O:29][C:30]1[CH:31]=[CH:32][CH:33]=[C:34]2[C:38]=1[CH:37]([NH2:39])[CH2:36][CH2:35]2>>[F:15][C:16]1[CH:17]=[C:18]([S:24]([NH:1][C:4]2[CH:13]=[CH:12][CH:11]=[C:10]3[C:5]=2[CH:6]=[CH:7][C:8]([NH:39][CH:37]2[C:38]4[C:34](=[CH:33][CH:32]=[CH:31][C:30]=4[O:29][CH3:28])[CH2:35][CH2:36]2)=[N:9]3)(=[O:26])=[O:25])[CH:19]=[C:20]([F:23])[C:21]=1[F:22]

Participants

4

Reactant 3

HCID 3192512-Chloro-5-nitroquinolineHCID 27788583,4,5-Trifluorobenzenesulfonyl chlorideHCID 186198817-Methoxy-2,3-dihydro-1H-inden-1-amine

Product 1

HCID 25019062Rac-3,4,5-trifluoro-n-[2-(7-methoxy-indan-1-ylamino)-quinolin-5-yl]-benzenesulfonamide

Procedure

The title compound, MS: m/e=500.0 (M+H+), was prepared in accordance with the general method of example 13 from 5-nitro-2-chloroquinoline, 3,4,5-trifluorobenzenesulfonyl chloride and rac-7-methoxy-indane-1-ylamine.

Sources & evidence

ORD record
ord-88be0c6849d24402a6f7ca940e3b7af6
Source dataset
uspto-grants-2011_04
Patent number
US07923561B2

Reaction notes

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