4-Fluorobenzenesulfonyl chloride → Rac-4-fluoro-n-[2-(7-methoxy-indan-1-ylamino)-quinolin-5-yl]-benzenesulfonamide

HRID 2076298Notes

Reaction equation

HRID 2076298 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](Cl)=[N:9]2)([O-])=O.[F:15][C:16]1[CH:21]=[CH:20][C:19]([S:22](Cl)(=[O:24])=[O:23])=[CH:18][CH:17]=1.[CH3:26][O:27][C:28]1[CH:29]=[CH:30][CH:31]=[C:32]2[C:36]=1[CH:35]([NH2:37])[CH2:34][CH2:33]2>>[F:15][C:16]1[CH:21]=[CH:20][C:19]([S:22]([NH:1][C:4]2[CH:13]=[CH:12][CH:11]=[C:10]3[C:5]=2[CH:6]=[CH:7][C:8]([NH:37][CH:35]2[C:36]4[C:32](=[CH:31][CH:30]=[CH:29][C:28]=4[O:27][CH3:26])[CH2:33][CH2:34]2)=[N:9]3)(=[O:24])=[O:23])=[CH:18][CH:17]=1

Participants

4

Reactant 3

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 3192512-Chloro-5-nitroquinolineHCID 186198817-Methoxy-2,3-dihydro-1H-inden-1-amine

Product 1

HCID 25019059Rac-4-fluoro-n-[2-(7-methoxy-indan-1-ylamino)-quinolin-5-yl]-benzenesulfonamide

Procedure

The title compound, MS: m/e=464.1 (M+H+), was prepared in accordance with the general method of example 13 from 5-nitro-2-chloroquinoline, 4-fluorobenzenesulfonyl chloride and rac-7-methoxy-indane-1-ylamine.

Sources & evidence

ORD record
ord-0d9aad90dd624467bc3066d85d740154
Source dataset
uspto-grants-2011_04
Patent number
US07923561B2

Reaction notes

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