2-Chloro-5-nitroquinoline → HCID 25017273, compound

HRID 2076300Notes

Reaction equation

HRID 2076300 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](Cl)=[N:9]2)([O-])=O.[F:15][C:16]1[CH:17]=[C:18]([S:23](Cl)(=[O:25])=[O:24])[CH:19]=[C:20]([F:22])[CH:21]=1.[O:27]1[C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=2[CH:29]([NH2:36])[CH2:28]1>>[O:27]1[C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=2[CH:29]([NH:36][C:8]2[CH:7]=[CH:6][C:5]3[C:10](=[CH:11][CH:12]=[CH:13][C:4]=3[NH:1][S:23]([C:18]3[CH:17]=[C:16]([F:15])[CH:21]=[C:20]([F:22])[CH:19]=3)(=[O:25])=[O:24])[N:9]=2)[CH2:28]1

Participants

4

Reactant 3

HCID 3192512-Chloro-5-nitroquinolineHCID 27740583,5-Difluorobenzenesulfonyl chlorideHCID 137781522,3-Dihydro-1-benzofuran-3-amine

Product 1

HCID 25017273HCID 25017273, compound

Procedure

The title compound, MS: m/e=454.3 (M+H+), was prepared in accordance with the general method of example 13 from 5-nitro-2-chloroquinoline, 3,5-difluorobenzenesulfonyl chloride and rac-2,3-dihydro-benzofuran-3-ylamine (CAS 109926-35-4).

Sources & evidence

ORD record
ord-0eaca432630f40a1afeaac384eeece8d
Source dataset
uspto-grants-2011_04
Patent number
US07923561B2

Reaction notes

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