2-Chloro-5-nitroquinoline → HCID 67095757, compound

HRID 2076303Notes

Reaction equation

HRID 2076303 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](Cl)=[N:9]2)([O-])=O.[F:15][C:16]1[CH:17]=[C:18]([S:23](Cl)(=[O:25])=[O:24])[CH:19]=[C:20]([F:22])[CH:21]=1.[CH2:27]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[C@@H:29]([NH2:36])[C@H:28]1[OH:37]>>[F:15][C:16]1[CH:17]=[C:18]([S:23]([NH:1][C:4]2[CH:13]=[CH:12][CH:11]=[C:10]3[C:5]=2[CH:6]=[CH:7][C:8]([NH:36][C@@H:29]2[C:30]4[C:35](=[CH:34][CH:33]=[CH:32][CH:31]=4)[CH2:27][C@@H:28]2[OH:37])=[N:9]3)(=[O:25])=[O:24])[CH:19]=[C:20]([F:22])[CH:21]=1

Participants

4

Reactant 3

HCID 3192512-Chloro-5-nitroquinolineHCID 2725045(1R,2S)-(+)-cis-1-Amino-2-indanolHCID 27740583,5-Difluorobenzenesulfonyl chloride

Product 1

HCID 67095757HCID 67095757, compound

Procedure

The title compound, MS: m/e=468.5 (M+H+), was prepared in accordance with the general method of example 13 from 5-nitro-2-chloroquinoline, 3,5-difluorobenzenesulfonyl chloride and (1R,2S)-(+)-cis-1-amino-2-indanol.

Sources & evidence

ORD record
ord-4faf9d9da5c84b1d8057f9459f4e1dd7
Source dataset
uspto-grants-2011_04
Patent number
US07923561B2

Reaction notes

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