Cyclopropanemethanamine → HCID 67095885, compound

Participants

Reaction Conditions

Reaction Steps

4-Fluoro-N-[2-((R)-indan-1-ylamino)-quinolin-5-yl]-benzenesulfonamide (product example 1, 0.175 g, 0.404 mmol) was suspended in 2 mL cyclopropanemethylamine. The reaction mixture was stirred in a sealed tube at 120° C. overnight. The reaction mixture was purified by flash chromatography on silica gel (heptan/ethyl acetate 100:0->50:50 gradient). The title compound was obtained as a white solid (46 mg, 24%), MS: m/e=485.5 (M+H+).

Provenance & Evidence