2-Chloro-5-nitroquinoline → HCID 67095956, compound

HRID 2076308Notes

Reaction equation

HRID 2076308 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](Cl)=[N:9]2)([O-])=O.[NH2:15][C@H:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:18][CH2:17]1.[CH3:25][N:26]1[CH:30]=[C:29]([S:31](Cl)(=[O:33])=[O:32])[N:28]=[CH:27]1>>[C@H:16]1([NH:15][C:8]2[CH:7]=[CH:6][C:5]3[C:10](=[CH:11][CH:12]=[CH:13][C:4]=3[NH:1][S:31]([C:29]3[N:28]=[CH:27][N:26]([CH3:25])[CH:30]=3)(=[O:33])=[O:32])[N:9]=2)[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:18][CH2:17]1

Participants

4

Reactant 3

HCID 3192512-Chloro-5-nitroquinolineHCID 2733933(R)-(-)-1-AminoindanHCID 27368871-methyl-1H-imidazole-4-sulfonyl chloride

Product 1

HCID 67095956HCID 67095956, compound

Procedure

The title compound, MS: m/e=420.3 (M+H+), was prepared in accordance with the general method of example 45 from 5-nitro-2-chloroquinoline, (R)-1-aminoindane and 1-methylimidazol-4-sulfonylchloride.

Sources & evidence

ORD record
ord-c843c0a51dc74ee2903bb5d816c17ecf
Source dataset
uspto-grants-2011_04
Patent number
US07923561B2

Reaction notes

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