2-Chloro-5-nitroquinoline → HCID 67096010, compound

HRID 2076310Notes

Reaction equation

HRID 2076310 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](Cl)=[N:9]2)([O-])=O.[F:15][C:16]1[CH:17]=[C:18]([S:23](Cl)(=[O:25])=[O:24])[CH:19]=[C:20]([F:22])[CH:21]=1.[NH2:27][C@H:28]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH2:30][C@H:29]1[OH:37]>>[F:15][C:16]1[CH:17]=[C:18]([S:23]([NH:1][C:4]2[CH:13]=[CH:12][CH:11]=[C:10]3[C:5]=2[CH:6]=[CH:7][C:8]([NH:27][C@H:28]2[C:36]4[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=4)[CH2:30][C@H:29]2[OH:37])=[N:9]3)(=[O:25])=[O:24])[CH:19]=[C:20]([F:22])[CH:21]=1

Participants

4

Reactant 3

HCID 3192512-Chloro-5-nitroquinolineHCID 27740583,5-Difluorobenzenesulfonyl chlorideHCID 9866743(1S,2R)-(-)-1-Amino-2-indanol

Product 1

HCID 67096010HCID 67096010, compound

Procedure

The title compound, MS: m/e=468.5 (M+H+), was prepared in accordance with the general method of example 13 from 5-nitro-2-chloroquinoline, 3,5-difluorobenzenesulfonyl chloride and (1S,2R)-(−)-1-amino-2-indanol.

Sources & evidence

ORD record
ord-b5d7636a74914bbfbf50473f368fd5f9
Source dataset
uspto-grants-2011_04
Patent number
US07923561B2

Reaction notes

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