2-Chloro-5-nitroquinoline → HCID 67095807, compound

HRID 2076313Notes

Reaction equation

HRID 2076313 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](Cl)=[N:9]2)([O-])=O.[F:15][C:16]1[CH:17]=[C:18]([S:23](Cl)(=[O:25])=[O:24])[CH:19]=[C:20]([F:22])[CH:21]=1.[CH3:27][O:28][C:29]1[CH:30]=[CH:31][CH:32]=[C:33]2[C:38]=1[CH:37]([NH2:39])[CH2:36][CH2:35][CH2:34]2>>[F:15][C:16]1[CH:17]=[C:18]([S:23]([NH:1][C:4]2[CH:13]=[CH:12][CH:11]=[C:10]3[C:5]=2[CH:6]=[CH:7][C:8]([NH:39][CH:37]2[C:38]4[C:33](=[CH:32][CH:31]=[CH:30][C:29]=4[O:28][CH3:27])[CH2:34][CH2:35][CH2:36]2)=[N:9]3)(=[O:25])=[O:24])[CH:19]=[C:20]([F:22])[CH:21]=1

Participants

4

Reactant 3

HCID 3192512-Chloro-5-nitroquinolineHCID 27740583,5-Difluorobenzenesulfonyl chlorideHCID 221473568-Methoxy-1,2,3,4-tetrahydronaphthalen-1-amine

Product 1

HCID 67095807HCID 67095807, compound

Procedure

The title compound, MS: m/e=496.3 (M+H+), was prepared in accordance with the general method of example 13 from 5-nitro-2-chloroquinoline, 3,5-difluorobenzenesulfonyl chloride and 8-methoxy-1,2,3,4-tetrahydronaphthalen-1-amine (CAS 535935-61-6).

Sources & evidence

ORD record
ord-801371441c7449279f91ccc40136302e
Source dataset
uspto-grants-2011_04
Patent number
US07923561B2

Reaction notes

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