2-Methylphenyl boronic acid → HCID 25016241, compound

HRID 2076318Notes

Reaction equation

HRID 2076318 reaction equation
I[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6](Cl)=[N:7]2.[NH2:13][C@H:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][CH2:15]1.[C:23]1([CH3:32])[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1B(O)O>>[C@H:14]1([NH:13][C:6]2[CH:5]=[CH:4][C:3]3[C:8](=[CH:9][CH:10]=[CH:11][C:2]=3[C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=3[CH3:32])[N:7]=2)[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][CH2:15]1

Participants

4

Reactant 3

HCID 27332672-Methylphenyl boronic acidHCID 2733933(R)-(-)-1-AminoindanHCID 457894242-Chloro-5-iodoquinoline

Product 1

HCID 25016241HCID 25016241, compound

Procedure

The title compound, MS: m/e=351.5 (M+H+), was prepared in accordance with the general method of example 63 from 5-iodo-2-chloroquinoline, (R)-1-aminoindane and ortho-tolylboronic acid.

Sources & evidence

ORD record
ord-5e105204630e4f63aaec88e93b73af92
Source dataset
uspto-grants-2011_04
Patent number
US07923561B2

Reaction notes

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