(R)-(-)-1-Aminoindan → HCID 25016497, compound

HRID 2076319Notes

Reaction equation

HRID 2076319 reaction equation
I[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6](Cl)=[N:7]2.[NH2:13][C@H:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][CH2:15]1.[N:23]1[CH:28]=[CH:27][CH:26]=[C:25](B(O)O)[CH:24]=1>>[C@H:14]1([NH:13][C:6]2[CH:5]=[CH:4][C:3]3[C:8](=[CH:9][CH:10]=[CH:11][C:2]=3[C:25]3[CH:24]=[N:23][CH:28]=[CH:27][CH:26]=3)[N:7]=2)[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][CH2:15]1

Participants

4

Reactant 3

HCID 2733933(R)-(-)-1-AminoindanHCID 27343783-Pyridinylboronic acidHCID 457894242-Chloro-5-iodoquinoline

Product 1

HCID 25016497HCID 25016497, compound

Procedure

The title compound, MS: m/e=338.4 (M+H+), was prepared in accordance with the general method of example 63 from 5-iodo-2-chloroquinoline, (R)-1-aminoindane and 3-pyridylboronic acid.

Sources & evidence

ORD record
ord-144a80d800af46d999a4d641c06aad00
Source dataset
uspto-grants-2011_04
Patent number
US07923561B2

Reaction notes

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