2-Chloro-5-nitroquinoline → HCID 178488325, compound

HRID 2076320Notes

Reaction equation

HRID 2076320 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](Cl)=[N:9]2)([O-])=O.[CH3:15][O:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[C:26]=1[CH:25]([NH2:27])[CH2:24][CH2:23][CH2:22]2.[NH:28]1[CH:32]=[C:31]([CH:33]=O)[N:30]=[N:29]1>>[CH3:15][O:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[C:26]=1[CH:25]([NH:27][C:8]1[CH:7]=[CH:6][C:5]3[C:4]([NH:1][CH2:33][C:31]4[N:30]=[N:29][NH:28][CH:32]=4)=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=1)[CH2:24][CH2:23][CH2:22]2

Participants

4

Reactant 3

HCID 3192512-Chloro-5-nitroquinolineHCID 221473568-Methoxy-1,2,3,4-tetrahydronaphthalen-1-amineHCID 178519887HCID 178519887, compound

Product 1

HCID 178488325HCID 178488325, compound

Procedure

The title compound, MS: m/e=401.5 (M+H+), was prepared in accordance with the general method of example 43 from 5-nitro-2-chloroquinoline, rac-8-methoxy-1,2,3,4-tetrahydronaphthalen-1-amine (CAS 535935-61-6) and 1H-1,2,3-triazole-4-carbaldehyde.

Sources & evidence

ORD record
ord-fb6df55b821440cd943016731cc18f14
Source dataset
uspto-grants-2011_04
Patent number
US07923561B2

Reaction notes

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