2-Chloro-5-nitroquinoline → HCID 25016760, compound

HRID 2076321Notes

Reaction equation

HRID 2076321 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](Cl)=[N:9]2)([O-])=O.[CH3:15][O:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[C:26]=1[CH:25]([NH2:27])[CH2:24][CH2:23][CH2:22]2.[CH:28]([C:30]1[CH:38]=[CH:37][CH:36]=[C:35]2[C:31]=1[CH:32]=[CH:33][NH:34]2)=O>>[NH:34]1[C:35]2[C:31](=[C:30]([CH2:28][NH:1][C:4]3[C:5]4[CH:6]=[CH:7][C:8]([NH:27][CH:25]5[C:26]6[C:21](=[CH:20][CH:19]=[CH:18][C:17]=6[O:16][CH3:15])[CH2:22][CH2:23][CH2:24]5)=[N:9][C:10]=4[CH:11]=[CH:12][CH:13]=3)[CH:38]=[CH:37][CH:36]=2)[CH:32]=[CH:33]1

Participants

4

Reactant 3

HCID 3192512-Chloro-5-nitroquinolineHCID 333703Indole-4-carboxaldehydeHCID 221473568-Methoxy-1,2,3,4-tetrahydronaphthalen-1-amine

Product 1

HCID 25016760HCID 25016760, compound

Procedure

The title compound, MS: m/e=449.3 (M+H+), was prepared in accordance with the general method of example 43 from 5-nitro-2-chloroquinoline, rac-8-methoxy-1,2,3,4-tetrahydronaphthalen-1-amine (CAS 535935-61-6) and 4-formylindole.

Sources & evidence

ORD record
ord-b3185bbdb8694645b5b8cdc3a8c5b977
Source dataset
uspto-grants-2011_04
Patent number
US07923561B2

Reaction notes

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