(R)-(-)-1-Aminoindan → HCID 25016498, compound

HRID 2076322Notes

Reaction equation

HRID 2076322 reaction equation
I[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6](Cl)=[N:7]2.[NH2:13][C@H:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][CH2:15]1.[NH:23]1[C:31]2[CH:30]=[CH:29][CH:28]=[C:27](B(O)O)[C:26]=2[CH:25]=[CH:24]1>>[C@H:14]1([NH:13][C:6]2[CH:5]=[CH:4][C:3]3[C:8](=[CH:9][CH:10]=[CH:11][C:2]=3[C:27]3[CH:28]=[CH:29][CH:30]=[C:31]4[C:26]=3[CH:25]=[CH:24][NH:23]4)[N:7]=2)[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][CH2:15]1

Participants

4

Reactant 3

HCID 2733933(R)-(-)-1-AminoindanHCID 27631731H-Indole-4-boronic acidHCID 457894242-Chloro-5-iodoquinoline

Product 1

HCID 25016498HCID 25016498, compound

Procedure

The title compound, MS: m/e=376.5 (M+H+), was prepared in accordance with the general method of example 63 from 5-iodo-2-chloroquinoline, (R)-1-aminoindane and 1H-indole-4-boronic acid.

Sources & evidence

ORD record
ord-728bf6daa585458f869bfaefdc3920f8
Source dataset
uspto-grants-2011_04
Patent number
US07923561B2

Reaction notes

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