4-Fluorobenzoyl chloride → HCID 67095875, compound

HRID 2076324Notes

Reaction equation

HRID 2076324 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](Cl)=[N:9]2)([O-])=O.[NH2:15][C@H:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:18][CH2:17]1.[F:25][C:26]1[CH:34]=[CH:33][C:29]([C:30](Cl)=[O:31])=[CH:28][CH:27]=1>>[F:25][C:26]1[CH:34]=[CH:33][C:29]([C:30]([NH:1][C:4]2[CH:13]=[CH:12][CH:11]=[C:10]3[C:5]=2[CH:6]=[CH:7][C:8]([NH:15][C@H:16]2[C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[CH2:18][CH2:17]2)=[N:9]3)=[O:31])=[CH:28][CH:27]=1

Participants

4

Reactant 3

HCID 678794-Fluorobenzoyl chlorideHCID 3192512-Chloro-5-nitroquinolineHCID 2733933(R)-(-)-1-Aminoindan

Product 1

HCID 67095875HCID 67095875, compound

Procedure

The title compound, MS: m/e=398.1 (M+H+), was prepared in accordance with the general method of example 45 from 5-nitro-2-chloroquinoline, (R)-1-aminoindane and 4-fluorobenzoyl chloride.

Sources & evidence

ORD record
ord-bcd2a2f5a81e4bd990dd61d9df23efb9
Source dataset
uspto-grants-2011_04
Patent number
US07923561B2

Reaction notes

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