反应详情

To a suspension of 3-acetyl-7,8-dihydrocyclopenta[e]indazol-6(3H) -one (9.19 g, 42.9 mmol) in methanol (250 mL) was added 1N aqueous sodium hydroxide (55.6 mL, 55.6 mmol). The resulting brown solution was stirred at room temperature for 1 hour. The methanol was evaporated under vacuum and the residue was diluted with water (250 mL) and adjusted to pH 4 with 6N aqueous HCl. The resulting precipitate was isolated by filtration, washed thoroughly with water and dried under vacuum to give 7,8-dihydrocyclopenta[e]indazol-6(3H)-one as a yellow solid.

1. customThe methanol was evaporated under vacuum
2. additionthe residue was diluted with water (250 mL)
3. customThe resulting precipitate was isolated by filtration
4. washwashed thoroughly with water
5. customdried under vacuum