Potassium Hydroxide → 119454-82-9

Participants

Reaction Conditions

Reaction Steps

In a 50 mL round bottom flask was charged methyl 4-((E)-2-(1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalen-6-yl)vinyl)benzoate 10 (0.30 g, 0.86 mmol) in 20 mL and water (2 mL) and KOH was added (193 mg, 3.44 mmol). The suspension was heated for 6 h at 70° C. Methanol was removed in vacuo, water (20 mL) was added and the solution washed with diethyl ether (2×30 mL). The aqueous solution was carefully acidified to pH=1 using a solution of HCl 1N and extracted with diethyl ether (3×100 ml). The organic layer was dried over MgSO4, filtered and evaporated to yield to 4-((E)-2-(1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalen-6-yl)vinyl)benzoic acid 12 (0.26 g, 90% yield) as a white solid.

Provenance & Evidence