Potassium Hydroxide → HCID 10088269, compound

Participants

Reaction Conditions

Reaction Steps

In a 50 mL round bottom flask was charged methyl 4-((Z)-2-(1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalen-6-yl)vinyl)benzoate 11 (0.16 g, 0.46 mmol) in 15 mL and water (1.5 mL) and KOH was added (103 mg, 1.84 mmol). The suspension was heated for 6 h at 70° C. Methanol was removed in vacuo, water (20 mL) was added and the solution washed with diethyl ether (2×50 mL). The aqueous solution was carefully acidified to pH=1 using a solution of HCl 1N and extracted with diethyl ether (3×50 ml). The organic layer was dried over MgSO4, filtered and evaporated to yield to 4-((Z)-2-(1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalen-6-yl)vinyl)benzoic acid 13 (0.151 g, 98% yield) as a white solid.

Provenance & Evidence