Potassium Hydroxide → HCID 23075282, compound

Participants

Reaction Steps

A 25 mL round bottom flask equipped with a reflux condenser was charged with methyl (1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalen-7-ylcarbamoyl)formate 24 (0.200 g, 0.691 mmol), MeOH (10 mL) and KOH (0.078 g, 1.382 mmol). The reaction mixture was stirred for 3 h at reflux, evaporated to dryness and partitioned between EtOAc and H2O. 6N HCl was added to reach acidic pH and the organic layer was separated, washed with water, brine, dried with Na2SO4, filtered and concentrated on a rotary evaporator to give (1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalen-7-ylcarbamoyl)formic acid as a white solid 25 (0.157 g, 83% yield).

Provenance & Evidence