Azobisisobutyronitrile → HCID 67119147, compound

Participants

Reaction Steps

N-Bromosuccinimide (1.18 g, 6.63 mmol) and 2,2′-azobis(isobutyronitrile) (20 mg) were added to a solution of tert-butyl 2-methyl-5-(trifluoromethyl)benzoate (1.57 g, 6.03 mmol) obtained in Example (2-1) in benzene (25 ml) and the mixture was heated under reflux for 60 minutes. The temperature of the reaction mixture was returned to room temperature and the residue obtained by removing the solvent under reduced pressure was purified by silica gel column chromatography (eluting solvent: n-hexane/ethyl acetate=8/1-6/1) to give tert-butyl 2-(bromomethyl)-5-(trifluoromethyl)benzoate as a white powder (1.08, yield: 53%).

Provenance & Evidence