Methyl (4'-hydroxybiphenyl-3-yl)acetate → Methyl (4'-{[2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzyl]oxy}-1,1'-biphenyl-3-yl)acetate

HRID 2076593Notes

Reaction equation

HRID 2076593 reaction equation
[CH3:1][O:2][CH:3]([O:20][CH3:21])[C:4]1[C:9]([O:10][CH2:11][O:12][CH3:13])=[C:8]([C:14]([F:17])([F:16])[F:15])[CH:7]=[CH:6][C:5]=1[CH2:18][OH:19].O[C:23]1[CH:28]=[CH:27][C:26]([C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([CH2:35][C:36]([O:38][CH3:39])=[O:37])[CH:30]=2)=[CH:25][CH:24]=1>>[CH3:21][O:20][CH:3]([O:2][CH3:1])[C:4]1[C:9]([O:10][CH2:11][O:12][CH3:13])=[C:8]([C:14]([F:15])([F:16])[F:17])[CH:7]=[CH:6][C:5]=1[CH2:18][O:19][C:23]1[CH:24]=[CH:25][C:26]([C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([CH2:35][C:36]([O:38][CH3:39])=[O:37])[CH:30]=2)=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 59219036Methyl (4'-hydroxybiphenyl-3-yl)acetateHCID 67119352[2-(Dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)phenyl]methanol

Product 1

HCID 86617397Methyl (4'-{[2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzyl]oxy}-1,1'-biphenyl-3-yl)acetateYield 549%

Procedure

According to a method similar to Example (6-7), from [2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)phenyl]methanol (1.96 g, 6.32 mmol) obtained in Example (6-6) and methyl (4′-hydroxy-1,1′-biphenyl-3-yl)acetate (1.68 g, 6.95 mmol) obtained in Example (8-1), methyl (4′-{[2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzyl]oxy}-1,1′-biphenyl-3-yl)acetate was obtained (1.83 g, yield: 549%).

Sources & evidence

ORD record
ord-e29fc7d94ee44428a8f96aa264b5a8ed
Source dataset
uspto-grants-2011_04
Patent number
US07923573B2

Reaction notes

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