4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → HCID 67119165, compound

HRID 2076598Notes

Reaction equation

HRID 2076598 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#[N:10])=[C:4]([F:11])[CH:3]=1.CC1(C)C(C)(C)OB([C:20]2[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=2)O1>>[F:11][C:4]1[CH:3]=[C:2]([C:20]2[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=2)[CH:7]=[CH:6][C:5]=1[CH2:8][C:9]#[N:10]

Participants

3

Reactant 2

HCID 27346244-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenolHCID 71723082-(4-Bromo-2-fluorophenyl)acetonitrile

Product 1

HCID 67119165HCID 67119165, compound

Procedure

According to a method similar to Example (8-1), from (4-bromo-2-fluorophenyl)acetonitrile (3.0 g, 14 mmol) obtained in Example (11-1) and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (3.45 g, 14 mmol), (3-fluoro-4′-hydroxy-1,1′-biphenyl-4-yl)acetonitrile was obtained as a colorless solid (2.9 g, yield: 91%).

Sources & evidence

ORD record
ord-a4bbf81daebc470a99b1b96b668f8775
Source dataset
uspto-grants-2011_04
Patent number
US07923573B2

Reaction notes

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