[2-(Dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)phenyl]methanol → Allyl (4'-{[2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzyl]oxy}-3'-fluoro-1,1'-biphenyl-4-yl)acetate

Participants

Reaction Steps

According to a method similar to Example (6-7), from allyl (3′-fluoro-4′-hydroxy-1,1′-biphenyl-4-yl)acetate (300 mg, 1.05 mmol) obtained in Example (12-2) and [2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)phenyl]methanol (500 mg, 1.61 mmol) obtained in Example (6-6), allyl (4′-{[2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzyl]oxy}-3′-fluoro-1,1′-biphenyl-4-yl)acetate was obtained (618 mg, yield: 93%).

Provenance & Evidence