Methyl (2'-fluoro-4'-hydroxy-1,1'-biphenyl-4-yl)acetate → Methyl (4'-{[2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzyl]oxy}-2'-fluoro-1,1'-biphenyl-4-yl)acetate

Participants

Reaction Steps

According to a method similar to Example (6-7), from methyl (2′-fluoro-4′-hydroxy-1,1′-biphenyl-4-yl)acetate (1.02 g, 3.94 mmol) obtained in Example (14-1) and [2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)phenyl]methanol (1.71 g, 5.52 mmol) obtained in Example (6-6), methyl (4′-{[2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzyl]oxy}-2′-fluoro-1,1′-biphenyl-4-yl)acetate was obtained (2.01 g, yield: 92%).

Provenance & Evidence