Hydrochloric Acid → HCID 67119157, compound

Participants

Reaction Steps

A 1N aqueous sodium hydroxide solution (3.0 ml, 3.0 mmol) and methanol (0.5 ml) were added to a solution of tert-butyl 2-hydroxy-6-[({4′-[(methoxycarbonyl)methyl]-3′-methyl-1,1′-biphenyl-4-yl}oxy)methyl]-3-(trifluoromethyl)benzoate (667 mg, 1.26 mmol) obtained in Example (17-3) in tetrahydrofuran (8.5 ml), and the mixture was stirred at room temperature for 6 hours. After the reaction mixture was poured into 0.5N hydrochloric acid and the mixture was extracted with ethyl acetate (three times), the organic layer was successively washed with water and a saturated aqueous NaCl solution and dried with anhydrous sodium sulfate. The residue obtained by removing the solvent under reduced pressure was crystallized from a mixture solvent of ethanol-ethyl acetate to give the title compound as a colorless powder (552 mg, yield: 84%).

Provenance & Evidence