Tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate → (4'-{[2-(tert-Butoxycarbonyl)-3-hydroxy-4-(trifluoromethyl)benzyl]oxy}-2-chloro-1,1'-biphenyl-4-yl)acetic acid

Participants

Reaction Steps

According to a method similar to Example (2-3), Example (33-5) and Example (17-4), from methyl (2-chloro-4′-hydroxy-1,1′-biphenyl-4-yl)acetate (150 mg, 0.54 mmol) obtained in Example (23-3) and tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate (455 mg, 1.0 mmol) obtained in Example (28-5), the title compound was obtained as a colorless compound (46 mg, three-step total yield: 15%).

Provenance & Evidence