Tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate → [2-(4-{[2-(tert-Butoxycarbonyl)-3-hydroxy-4-(trifluoromethyl)benzyl]oxy}phenyl)-1,3-thiazol-5-yl]acetic acid

Participants

Reaction Steps

According to a method similar to Example (2-3), Example (33-5) and Example (11-7), from tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate (314 mg, 0.69 mmol) obtained in Example (28-5) and allyl[2-(4-hydroxyphenyl)-1,3-thiazol-5-yl]acetate (190 mg, 0.69 mmol) obtained in Example (30-2), the title compound was obtained as a colorless powder (33 mg, three-step total yield: 9%).

Provenance & Evidence