Pyrrolidine → HCID 67119126, compound

Participants

Reaction Conditions

Reaction Steps

Pyrrolidine (3 μl, 0.036 mmol) was added to a solution of tert-butyl 2-[(tert-butoxycarbonyl)oxy]-6-[({3′-[(methoxycarbonyl)methyl]-2′-methyl-1,1′-biphenyl-4-yl}oxy)methyl]-3-(trifluoromethyl)benzoate (19 mg, 0.030 mmol) obtained in Example (33-4) in tetrahydrofuran (1 ml), and the mixture was stirred at 40° C. for 1 hour. The residue obtained by removing the solvent under reduced pressure was purified by silica gel preparative thin layer chromatography (developing solvent: n-hexane/ethyl acetate=3/1) to give tert-butyl 2-hydroxy-6-[({3′-[(methoxycarbonyl)methyl]-2′-methyl-1,1′-biphenyl-4-yl}oxy)methyl]-3-(trifluoromethyl)benzoate as a colorless oil (16 mg, yield: 100%).

Provenance & Evidence