HRID2076647

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)Oc1c(C(F)(F)F)ccc(CBr)c1C(=O)OC(C)(C)C

HCID67119234

未命名化合物

结构：COC(=O)Cc1ccc(-c2ccc(O)cc2)c([N+](=O)[O-])c1

HCID86088130

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)c1c(COc2ccc(-c3ccc(CC(=O)O)cc3[N+](=O)[O-])cc2)ccc(C(F)(F)F)c1O

HCID11570241

未命名化合物

收率 7%

PROCEDURE

实验过程

According to a method similar to Example (40-2), Example (33-5) and Example (17-4), from methyl (4′-hydroxy-2-nitro-1,1′-biphenyl-4-yl)acetate (1.71 g, 3.76 mmol) obtained in Example (37-1) and tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate (1.08 g, 3.76 mmol) obtained in Example (28-5), the title compound was obtained as a yellow oil (138 mg, three-step total yield: 7%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-91b0d7bea2a24cbcabff8bbb3f2d977c
来源数据集: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07923573B2
来源说明: uspto-grants-2011_04

反应 SMILES

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][C:15]([O:17]C)=[O:16])=[CH:10][C:9]=2[N+:19]([O-:21])=[O:20])=[CH:4][CH:3]=1.Br[CH2:23][C:24]1[C:29]([C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])=[C:28]([O:37]C(OC(C)(C)C)=O)[C:27]([C:45]([F:48])([F:47])[F:46])=[CH:26][CH:25]=1>>[C:33]([O:32][C:30]([C:29]1[C:28]([OH:37])=[C:27]([C:45]([F:46])([F:47])[F:48])[CH:26]=[CH:25][C:24]=1[CH2:23][O:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][C:15]([OH:17])=[O:16])=[CH:10][C:9]=2[N+:19]([O-:21])=[O:20])=[CH:4][CH:3]=1)=[O:31])([CH3:36])([CH3:34])[CH3:35]