反应详情

Rhodium-alumina (Rh 5%) (100 mg) was added to a solution of (4′-{[2-(tert-butoxycarbonyl)-3-hydroxy-4-(trifluoromethyl)benzyl]oxy}-2-nitro-1,1′-biphenyl-4-yl)acetic acid (130 mg, 0.237 mmol) obtained in Example (37-2) in methanol (4 ml), and the mixture was stirred at room temperature under a hydrogen atmosphere for 2 days. The insolubles were removed by filtration through Celite and the filtrate was concentrated. The obtained residue was purified by silica gel preparative thin layer chromatography (developing solvent: methylene chloride/methanol=20/1) to give the title compound as a yellow amorphous compound (63 mg, yield: 51%).

1. customThe insolubles were removed by filtration through Celite
2. concentrationthe filtrate was concentrated
3. customThe obtained residue was purified by silica gel preparative thin layer chromatography (developing solvent: methylene chloride/methanol=20/1)