Tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate → Tert-butyl 2-[(tert-butoxycarbonyl)oxy]-6-[({2'-formyl-4'-[(methoxycarbonyl)methyl]-1,1'-biphenyl-4-yl}oxy)methyl]-3-(trifluoromethyl)benzoate
Reaction equation
Br[CH2:2][C:3]1[C:8]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])=[C:7]([O:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C:6]([C:24]([F:27])([F:26])[F:25])=[CH:5][CH:4]=1.[CH:28]([C:30]1[CH:35]=[C:34]([CH2:36][C:37]([O:39][CH3:40])=[O:38])[CH:33]=[CH:32][C:31]=1[C:41]1[CH:46]=[CH:45][C:44]([OH:47])=[CH:43][CH:42]=1)=[O:29]>>[C:20]([O:19][C:17]([O:16][C:7]1[C:6]([C:24]([F:25])([F:26])[F:27])=[CH:5][CH:4]=[C:3]([CH2:2][O:47][C:44]2[CH:43]=[CH:42][C:41]([C:31]3[CH:32]=[CH:33][C:34]([CH2:36][C:37]([O:39][CH3:40])=[O:38])=[CH:35][C:30]=3[CH:28]=[O:29])=[CH:46][CH:45]=2)[C:8]=1[C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])=[O:18])([CH3:21])([CH3:22])[CH3:23]Participants
3
Reactant 2
Product 1
Procedure
According to a method similar to Example (2-3), from tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate (3.60 g, 8.56 mmol) obtained in Example (28-5) and methyl (2-formyl-4′-hydroxy-1,1′-biphenyl-4-yl)acetate (2.10 g, 7.78 mmol) obtained in Example (45-1), tert-butyl 2-[(tert-butoxycarbonyl)oxy]-6-[({2′-formyl-4′-[(methoxycarbonyl)methyl]-1,1′-biphenyl-4-yl}oxy)methyl]-3-(trifluoromethyl)benzoate was obtained (3.06 g, yield: 61%).
Sources & evidence
- ORD record
- ord-991935c750ce46fbb5d18ce9cbd48741
- Source dataset
- uspto-grants-2011_04
- Patent number
- US07923573B2
Reaction notes
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