HRID2076657

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)Oc1c(C(F)(F)F)ccc(CBr)c1C(=O)OC(C)(C)C

HCID67119234

未命名化合物

HCID86087981

未命名化合物

PRODUCTS

生成物

结构：COC(=O)Cc1ccc(-c2ccc(OCc3ccc(C(F)(F)F)c(OC(=O)OC(C)(C)C)c3C(=O)OC(C)(C)C)cc2)c(C=O)c1

HCID86617414

未命名化合物

收率 61%

PROCEDURE

实验过程

According to a method similar to Example (2-3), from tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate (3.60 g, 8.56 mmol) obtained in Example (28-5) and methyl (2-formyl-4′-hydroxy-1,1′-biphenyl-4-yl)acetate (2.10 g, 7.78 mmol) obtained in Example (45-1), tert-butyl 2-[(tert-butoxycarbonyl)oxy]-6-[({2′-formyl-4′-[(methoxycarbonyl)methyl]-1,1′-biphenyl-4-yl}oxy)methyl]-3-(trifluoromethyl)benzoate was obtained (3.06 g, yield: 61%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-991935c750ce46fbb5d18ce9cbd48741
来源数据集: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07923573B2
来源说明: uspto-grants-2011_04

反应 SMILES

Br[CH2:2][C:3]1[C:8]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])=[C:7]([O:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C:6]([C:24]([F:27])([F:26])[F:25])=[CH:5][CH:4]=1.[CH:28]([C:30]1[CH:35]=[C:34]([CH2:36][C:37]([O:39][CH3:40])=[O:38])[CH:33]=[CH:32][C:31]=1[C:41]1[CH:46]=[CH:45][C:44]([OH:47])=[CH:43][CH:42]=1)=[O:29]>>[C:20]([O:19][C:17]([O:16][C:7]1[C:6]([C:24]([F:25])([F:26])[F:27])=[CH:5][CH:4]=[C:3]([CH2:2][O:47][C:44]2[CH:43]=[CH:42][C:41]([C:31]3[CH:32]=[CH:33][C:34]([CH2:36][C:37]([O:39][CH3:40])=[O:38])=[CH:35][C:30]=3[CH:28]=[O:29])=[CH:46][CH:45]=2)[C:8]=1[C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])=[O:18])([CH3:21])([CH3:22])[CH3:23]