HRID2076665

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14571696

Methyl 4-bromo-α-hydroxybenzeneacetate

C9H9BrO3

结构：CC(C)(C)OC(=O)c1c(COc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)ccc(C(F)(F)F)c1O

HCID67119153

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)c1c(COc2ccc(-c3ccc(C(O)C(=O)O)cc3)cc2)ccc(C(F)(F)F)c1O

HCID67119069

未命名化合物

PROCEDURE

实验过程

According to a method similar to Example (31) and Example (17-4), from methyl (4-bromophenyl)(hydroxy)acetate (100 mg, 0.41 mmol) and tert-butyl 2-hydroxy-6-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl}-3-(trifluoromethyl)benzoate (170 mg, 0.34 mmol) obtained in Example (22-4), the title compound was obtained as a grayish white powder (14 mg, yield: 8%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b051f573660d425093019e0a6009414e
来源数据集: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07923573B2
来源说明: uspto-grants-2011_04

反应 SMILES

Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:13])[C:9]([O:11]C)=[O:10])=[CH:4][CH:3]=1.[OH:14][C:15]1[C:27]([C:28]([F:31])([F:30])[F:29])=[CH:26][CH:25]=[C:24]([CH2:32][O:33][C:34]2[CH:39]=[CH:38][C:37](B3OC(C)(C)C(C)(C)O3)=[CH:36][CH:35]=2)[C:16]=1[C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18]>>[C:20]([O:19][C:17]([C:16]1[C:15]([OH:14])=[C:27]([C:28]([F:29])([F:30])[F:31])[CH:26]=[CH:25][C:24]=1[CH2:32][O:33][C:34]1[CH:39]=[CH:38][C:37]([C:2]2[CH:7]=[CH:6][C:5]([CH:8]([OH:13])[C:9]([OH:11])=[O:10])=[CH:4][CH:3]=2)=[CH:36][CH:35]=1)=[O:18])([CH3:23])([CH3:21])[CH3:22]