Ethylamine hydrochloride → tert-Butyl 6-[({4'-[2-(ethylamino) 2-oxoethyl]-1,1'-biphenyl-4-yl}oxy)methyl]-2-hydroxy-3-(trifluoromethyl)benzoate

Participants

Reaction Steps

According to a method similar to Example (49), from (4′-{[2-(tert-butoxycarbonyl)-3-hydroxy-4-(trifluoromethyl)benzyl]oxy}-1,1′-biphenyl-4-yl)acetic acid (187 mg, 0.374 mmol) obtained in Example (7) and ethylamine hydrochloride (61 mg, 0.75 mmol), the title compound was obtained as a colorless powder (129 mg, yield: 65%).

Provenance & Evidence