methyl 3-(4-bromophenyl)propanoate → HCID 67119235, compound

HRID 2076670Notes

Reaction equation

HRID 2076670 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([O:12]C)=[O:11])=[CH:4][CH:3]=1.[OH:14][C:15]1[C:27]([C:28]([F:31])([F:30])[F:29])=[CH:26][CH:25]=[C:24]([CH2:32][O:33][C:34]2[CH:39]=[CH:38][C:37](B3OC(C)(C)C(C)(C)O3)=[CH:36][CH:35]=2)[C:16]=1[C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18]>>[C:20]([O:19][C:17]([C:16]1[C:15]([OH:14])=[C:27]([C:28]([F:29])([F:30])[F:31])[CH:26]=[CH:25][C:24]=1[CH2:32][O:33][C:34]1[CH:39]=[CH:38][C:37]([C:2]2[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[CH:6][CH:7]=2)=[CH:36][CH:35]=1)=[O:18])([CH3:23])([CH3:21])[CH3:22]

Participants

3

Reactant 2

HCID 11447883methyl 3-(4-bromophenyl)propanoateHCID 67119153Tert-butyl 2-hydroxy-6-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl}-3-(trifluoromethyl)benzoate

Product 1

HCID 67119235HCID 67119235, compound

Procedure

According to a method similar to Example (31) and Example (17-4), from methyl 3-(4-bromophenyl)propionate (131 mg, 0.51 mmol) and tert-butyl 2-hydroxy-6-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]methyl}-3-(trifluoromethyl)benzoate (250 mg, 0.51 mmol) obtained in Example (22-4), the title compound was obtained as a colorless powder (26 mg, yield: 10%).

Sources & evidence

ORD record
ord-66b48af3148646188db11985fde8b66c
Source dataset
uspto-grants-2011_04
Patent number
US07923573B2

Reaction notes

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