Isopropanol → HCID 67119272, compound

Participants

Reaction Steps

Diethyl azodicarboxylate (108 μl, 0.68 mmol) was added to a solution of 2-(allyloxy)-6-{[(4′-{[(allyloxy)carbonyl]methyl}-1,1′-biphenyl-4-yl)oxy]methyl}-3-(trifluoromethyl)benzoic acid (150 mg, 0.29 mmol), 2-propanol (26 μl, 0.34 mmol) and triphenylphosphine (180 mg, 0.68 mmol) in tetrahydrofuran (3 ml) at room temperature. After the mixture was stirred at room temperature for 1 hour, the solvent of the reaction mixture was removed under reduced pressure. The obtained residue was purified by silica gel preparative thin layer chromatography (developing solvent: n-hexane/ethyl acetate=4/1) to give isopropyl 2-(allyloxy)-6-{[(4′-{[(allyloxy)carbonyl]methyl}-1,1′-biphenyl-4-yl)oxy]methyl}-3-(trifluoromethyl)benzoate (141 mg, yield: 87%).

Provenance & Evidence