HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-5-hydroxypyridine → HCID 86617426, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-5-hydroxypyridine | HCID 819821 | — |
| Reactant | Tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate | HCID 67119234 | — |
| Product | HCID 86617426 | HCID 86617426 | 84% |
Reaction Steps
According to a method similar to Example (2-3) and Example (33-5), from tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate (6.22 g, 13.7 mmol) obtained in Example (28-5) and 6-chloro-3-pyridinol (1.77 g, 13.7 mmol), tert-butyl 6-{[(6-chloro-3-pyridinyl)oxy]methyl}-2-hydroxy-3-(trifluoromethyl)benzoate was obtained (4.61 g, two-step total yield: 84%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07923573B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-2475453adb1a422f8a1fea083a59acd0 |
| Source note | uspto-grants-2011_04 |