HCID 86617428, compound → HCID 86617427, compound

Participants

Reaction Steps

Chlorotris(triphenylphosphine)rhodium (65 mg, 69.9 μmol) was added to a solution of methyl (4-bromo-2-ethynylphenyl)acetate (177 mg, 0.699 mmol) obtained in Example (85-2) in methanol (6 ml), and the mixture was stirred at room temperature under hydrogen atmosphere for 16 hours. The solvent was removed under reduced pressure and the obtained residue was purified by silica gel column chromatography (developing solvent: hexane/ethyl acetate=15/1) to give methyl (4-bromo-2-ethylphenyl)acetate (138 mg, yield: 77%).

Provenance & Evidence