4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → HCID 86241404, compound

HRID 2076684Notes

Reaction equation

HRID 2076684 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[C:4]([CH2:13][CH3:14])[CH:3]=1.CC1(C)C(C)(C)OB([C:23]2[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=2)O1>>[CH2:13]([C:4]1[CH:3]=[C:2]([C:23]2[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=2)[CH:7]=[CH:6][C:5]=1[CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH3:14]

Participants

3

Reactant 2

HCID 27346244-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenolHCID 86617427HCID 86617427, compound

Product 1

HCID 86241404HCID 86241404, compoundYield 84%

Procedure

According to a method similar to Example (26-3), from methyl (4-bromo-2-ethylphenyl)acetate (138 mg, 0.537 mmol) synthesized in Example (85-3) and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (142 mg, 0.644 mmol), methyl (3-ethyl-4′-hydroxy-1,1′-biphenyl-4-yl)acetate was obtained (122 mg, yield: 84%).

Sources & evidence

ORD record
ord-b0f371a6078c41018f849f2a6fb0f6fb
Source dataset
uspto-grants-2011_04
Patent number
US07923573B2

Reaction notes

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