Tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate → HCID 67119246, compound

Participants

Reaction Steps

According to a method similar to Example (2-3), Example (33-5) and Example (17-4), from methyl {3-[(dimethylamino)carbonyl]-4′-hydroxy-1,1′-biphenyl-4-yl}acetate (82 mg, 0.262 mmol) obtained in Example (89-1) and tert-butyl 6-(bromomethyl)-2-[(tert-butoxycarbonyl)oxy]-3-(trifluoromethyl)benzoate (131 mg, 0.288 mmol) obtained in Example (28-5), the title compound was obtained (100 mg, three-step total yield: 67%).

Provenance & Evidence