Water → HCID 67119374, compound

Participants

Reaction Steps

After methyl 2-ethyl-4′-methoxy-1,1′-biphenyl-3-carboxylate (4.83 g, 17.9 mmol) obtained in Example (90-2) was added to a suspension of lithium aluminum hydride (1.02 g, 26.8 mmol) in tetrahydrofuran (90 ml) under ice-cooling, the mixture was stirred at room temperature for 30 minutes. The reaction mixture was cooled with ice and water (1 ml) was added dropwise thereto. After the mixture was stirred for 5 minutes, a 3N aqueous sodium hydroxide solution (1 ml) was added thereto at room temperature and the mixture was stirred for 5 minutes. Further, water (3 ml) was added thereto and the mixture was stirred for 20 minutes. After the insolubles were removed by filtration using Celite, the solvent was removed under reduced pressure. The obtained residue was purified by silica gel column chromatography (eluting solvent: n-hexane/ethyl acetate=4/1-3/1) to give (2-ethyl-4′-methoxy-1,1′-biphenyl-3-yl)methanol (4.39 g, yield: 100%).

Provenance & Evidence