Thionyl Chloride → HCID 67119342, compound

Participants

Reaction Steps

After thionyl chloride (4 ml) was added to a solution of (2-ethyl-4′-methoxy-1,1′-biphenyl-3-yl)methanol (4.39 g, 17.9 mmol) obtained in Example (90-3) in methylene chloride (18 ml) under ice-cooling, the mixture was stirred at room temperature for 7 hours. The residue obtained by removing the solvent under reduced pressure was diluted with ethyl acetate and the mixture was successively washed with water, a saturated aqueous sodium hydrogencarbonate solution and a saturated aqueous NaCl solution and dried with anhydrous sodium sulfate. The solvent was removed under reduced pressure to give 3′-(chloromethyl)-2′-ethyl-1,1′-biphenyl-4-yl methyl ether (3.32 g, yield: 71%).

Provenance & Evidence