Potassium Cyanide → HCID 67119226, compound

Participants

Reaction Steps

An aqueous solution (7 ml) of potassium cyanide (829 mg, 12.7 mmol) was added dropwise to a solution of 3′-(chloromethyl)-2′-ethyl-1,1′-biphenyl-4-yl methyl ether (3.32 g, 12.7 mmol) obtained in Example (90-4) in N,N-dimethyl sulfoxide (7 ml) at 80° C., and the mixture was stirred at the same temperature for 3 hours. The reaction mixture was diluted with ethyl acetate and the organic layer was successively washed with water and a saturated aqueous NaCl solution and dried with anhydrous sodium sulfate. The residue obtained by removing the solvent under reduced pressure was purified by silica gel column chromatography (eluting solvent: n-hexane/ethyl acetate=9/1-3/1) to give (2-ethyl-4′-methoxy-1,1′-biphenyl-3-yl)acetonitrile (2.65 g, yield: 83%).

Provenance & Evidence