Water → HCID 67119298, compound

Participants

Reaction Steps

A tetra-n-butylammonium fluoride-11.0M tetrahydrofuran solution (0.39 ml, 0.391 mmol) was added to a solution of methyl 2-(4′-{[tert-butyl(dimethyl)silyl]oxy}-3-ethyl-1,1′-biphenyl-4-yl)propionate (104 mg, 283 mmol) obtained in Example (103-1) in tetrahydrofuran (5 ml), and the mixture was stirred at room temperature for 1.5 hours. After water was added to the reaction mixture and the mixture was extracted with ethyl acetate, the organic layer was washed with a saturated aqueous NaCl solution and dried with anhydrous sodium sulfate. The residue obtained by removing the solvent under reduced pressure was purified by silica gel column chromatography (developing solvent: hexane/ethyl acetate=3/1) to give methyl 2-(3-ethyl-4′-hydroxy-1,1′-biphenyl-4-yl)propionate (76 mg, 1009).

Provenance & Evidence