Aspirin → HCID 67546490, compound

HRID 2076720Notes

Reaction equation

HRID 2076720 reaction equation
[CH3:1][C:2]([O:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:10]=1[C:11]([OH:13])=[O:12])=[O:3].[N:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=2)=[CH:16][CH:15]=1.CCOCC>CCCCCC>[CH3:1][C:2]([O:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:10]=1[C:11]([OH:13])=[O:12])=[O:3].[N:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=2)=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 2244AspirinHCID 3283Diethyl EtherHCID 111074,4'-Bipyridine

Product 1

HCID 67546490HCID 67546490, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

50 mg (0.2775 mmol) aspirin and 22 mg (0.1388 mmol) 4,4′-bipyridine were dissolved in 4 mL hexane. 8 mL ether was added to the solution and allowed to stand for one hour, yielding colorless needles of a 2:1 aspirin/4,4′-bipyridine co-crystal, as shown in FIG. 46A-D. Alternatively, aspirin/4,4′-bipyridine (2:1 stoichiometry) can be made by grinding the solid ingredients in a pestle and mortar.

Sources & evidence

ORD record
ord-46764e96e43e48bda6e0d01238e49168
Source dataset
uspto-grants-2011_04
Patent number
US07927613B2

Reaction notes

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