反应详情

50 mg (0.2775 mmol) aspirin and 22 mg (0.1388 mmol) 4,4′-bipyridine were dissolved in 4 mL hexane. 8 mL ether was added to the solution and allowed to stand for one hour, yielding colorless needles of a 2:1 aspirin/4,4′-bipyridine co-crystal, as shown in FIG. 46A-D. Alternatively, aspirin/4,4′-bipyridine (2:1 stoichiometry) can be made by grinding the solid ingredients in a pestle and mortar.