Ibuprofen, (+-)- → HCID 67107968, compound

HRID 2076721Notes

Reaction equation

HRID 2076721 reaction equation
[OH:1][C:2]([CH:4]([C:6]1[CH:15]=[CH:14][C:9]([CH2:10][CH:11]([CH3:13])[CH3:12])=[CH:8][CH:7]=1)[CH3:5])=[O:3].[N:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=2)=[CH:18][CH:17]=1>CC(C)=O>[OH:3][C:2]([CH:4]([C:6]1[CH:7]=[CH:8][C:9]([CH2:10][CH:11]([CH3:12])[CH3:13])=[CH:14][CH:15]=1)[CH3:5])=[O:1].[N:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=2)=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 3672Ibuprofen, (+-)-HCID 111074,4'-Bipyridine

Product 1

HCID 67107968HCID 67107968, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

50 mg (0.242 mmol) racemic ibuprofen and 18 mg (0.0960 mmol) 4,4′-bipyridine were dissolved in 5 mL acetone. Slow evaporation of the solvent yielded colorless needles of a 2:1 ibuprofen/4,4′-bipyridine co-crystal, as shown in FIG. 47A-D.

Workup

  1. customevaporation of the solvent

Sources & evidence

ORD record
ord-ef6c8f2ec44643bba8e15f5a4786093d
Source dataset
uspto-grants-2011_04
Patent number
US07927613B2

Reaction notes

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