Flurbiprofen → HCID 67108267, compound

HRID 2076722Notes

Reaction equation

HRID 2076722 reaction equation
[CH3:1][CH:2]([C:16]([OH:18])=[O:17])[C:3]1[CH:4]=[CH:5][C:6]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[C:7]([F:9])[CH:8]=1.[N:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=2)=[CH:21][CH:20]=1>CC(C)=O>[CH3:1][CH:2]([C:16]([OH:18])=[O:17])[C:3]1[CH:4]=[CH:5][C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:7]([F:9])[CH:8]=1.[N:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=2)=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 3394FlurbiprofenHCID 111074,4'-Bipyridine

Product 1

HCID 67108267HCID 67108267, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

50 mg (0.2046 mmol) flurbiprofen and 15 mg (0.0960 mmol) 4,4′-bipyridine were dissolved in 3 mL acetone. Slow evaporation of the solvent yielded colorless needles of a 2:1 flurbiprofen/4,4′-bipyridine co-crystal, as shown in FIG. 48A-D.

Workup

  1. customevaporation of the solvent

Sources & evidence

ORD record
ord-aab93d89fc59459b86187c8e8b357dff
Source dataset
uspto-grants-2011_04
Patent number
US07927613B2

Reaction notes

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