HuagongsheHuagongshe Chemistry Print Report · For research reference only
Flurbiprofen → Flurbiprofen 1,2-bis(4-pyridyl)ethylene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Flurbiprofen | HCID 3394 | — |
| Reactant | Pyridine, 4,4'-(1E)-1,2-ethenediylbis- | HCID 776222 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Flurbiprofen 1,2-bis(4-pyridyl)ethylene | HCID 67286207 | — |
Reaction Steps
25 mg (0.1023 mmol) flurbiprofen and 10 mg (0.0548 mmol) trans-1,2-bis(4-pyridyl) ethylene were dissolved in 3 mL acetone. Slow evaporation of the solvent yielded colorless needles of a 2:1 flurbiprofen/1,2-bis(4-pyridyl) ethylene co-crystal, as shown in FIG. 49A-B.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07927613B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-d3341fbd05d24c95bf6336bcec8e3b17 |
| Source note | uspto-grants-2011_04 |