Ethanol → 572916-56-4

HRID 2076725Notes

Reaction equation

HRID 2076725 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]2[N:15]([C:16]([NH2:18])=[O:17])[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[CH:8]=[CH:7][C:5]=2[CH:6]=1.[C:19]([NH2:27])(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[N:22][CH:21]=1.CO.C(O)C>CS(C)=O>[CH:11]1[CH:12]=[CH:13][C:14]2[N:15]([C:16]([NH2:18])=[O:17])[C:4]3[CH:3]=[CH:2][CH:1]=[CH:6][C:5]=3[CH:7]=[CH:8][C:9]=2[CH:10]=1.[C:19]([NH2:27])(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[N:22][CH:21]=1

Participants

6

Reactant 4

HCID 702EthanolHCID 887MethanolHCID 936NicotinamideHCID 2554Carbamazepine

Product 1

HCID 45139237572916-56-4

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

25 mg (0.1058 mmol) carbamazepine and 12 mg (0.0982 mmol) nicotinamide were dissolved in 4 mL of DMSO, methanol or ethanol. Slow evaporation of the solvent yielded colorless needles of a 1:1 carbamazepine/nicotinamide co-crystal, as shown in FIG. 51.

Workup

  1. customevaporation of the solvent

Sources & evidence

ORD record
ord-4f4ebc9a494d427c9de8d471c4b8f910
Source dataset
uspto-grants-2011_04
Patent number
US07927613B2

Reaction notes

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